Apr 19, 2024 · Precision fermentation depends on the development of synthetic cell factories designed to maximize the production of desired compounds and minimize the production of other byproducts.
Aug 9, 2022 · Recent studies have shown that through the detection of the cell-specific perfusion rate and substrate metabolism, the perfusion rate can be automated and controlled with high precision to achieve a higher cell concentration, and the virus concentration can reach 1 × 10 10 virus/mL (Nikolay et al., 2020a). However, the operation of perfusion
Evaluation of bioreactor-processed engineered tissue. The main performance measure of a bioreactor system for tissue engineering is the quality of tissue it can produce prior to implantation into a patient.
The Biostat STR ®️ Generation 3 single-use bioreactors are engineered for ultimate upstream performance. Available with integrated Repligen XCell ® ATF Technology for intensified processes, the system simplifies process set-up and operation while eliminating the need for separate control hardware.
Sep 15, 2020 · The new Biostat STR Generation 3 single-use bioreactor and Biobrain automation platform supports intensified bioprocessing and integration to DCS systems inc
A concentric cylinder bioreactor has been developed to culture tissue engineered cartilage constructs under hydrodynamic loading. This bioreactor operates in a low shear stress environment, has a large growth area for construct production, allows for dynamic seeding of constructs, and provides for a uniform loading environment.
3 days ago · Bioreactor landfills generally are engineered systems that have higher initial capital costs and require additional monitoring and control during their operating life, but are expected to involve less monitoring over the duration of the post-closure period than conventional “dry tomb” landfills.
May 23, 2024 · Genetically Engineered Goats as Efficient Mammary Gland Bioreactors for Production of Recombinant Human Neutrophil Peptide 1 Using CRISPR/Cas9 Dongxu Li 1,†, Rihong Guo 2,3,†, Fang Chen 2,3, Jingang Wang 1, Feng Wang 1,* and Yongjie Wan 1,* 1 Jiangsu Livestock Embryo Engineering Laboratory, College of Animal Science and Technology,
A bioreactor is essentially a vat, usually made of stainless steel, allowing living cells to multiply in an environment that can nourish them and keep them healthy. The cells must be steadily but
Aug 3, 2020 · Biosensors contribute to selective, sensitive, and rapid tools for the disease diagnosis in tissue engineering applications. Compared to standard ELISA analytical technique, biosensors provide a strategy to real-time and on-site monitor micro biophysiological signals via the combination of biological, chemical, and physical technologies.
The eLAB® Advanced Bioreactor offers a specialized configuration tailored for microbial applications. It includes sensors of pH, O₂, temperature, foam levels, and Dissolved Oxygen. The gas performance it’s managed with integrated mass flow controllers for air and O₂ addition. The system boasts a double-wall vessel with a 6-blade Rushton
Usage of bioreactors in the field of tissue engineering has played a significant role in enabling a controlled and reproducible change in the formation of damaged tissue on being provided with specific factors. Owing to the scarcity seen in providing sufficient donor organs for transplantation there is a huge requirement for large-scale production of artificial organs. This cannot be achieved
Sep 30, 2008 · Background— There is an essential demand for tissue engineered autologous small-diameter vascular graft, which can function in arterial high pressure and flow circulation. We investigated the potential to engineer a three-layered robust and elastic artery using a novel hemodynamically-equivalent pulsatile bioreactor. and Results— Endothelial cells (ECs), smooth muscle cells (SMCs
Nov 1, 2023 · The authors thank the AO Spine and AO Foundation (Davos, Switzerland) for financial support through the 2022 AO Spine Discovery and Innovation Award (AOS-DIA-22-021-DEG: Intervertebral disc-on-a-chip: a precision-engineered platform for low back pain studies). Declaration of interests. The authors declare no conflicts of interest.
Mar 30, 2020 · The new Biostat STR Generation 3 single-use bioreactor and Biobrain automation platform offer increased predictability, monitoring and control during scale-u